Kate Excoffon
Ph.D.
DEPARTMENT OF BIOLOGICAL SCIENCES
Wright State University
United States of America
Biography
Education History: 2001-2008 Postdoctoral Scholar/Research Scientist, University of Iowa, IA, USA 1995-2000 Ph.D. Genetics, University of British Columbia, BC, Canada 1990-1994 B.Sc. Biochemistry and Genetics, University of Guelph, ON, Canada
Research Interest
Research in the Excoffon laboratory is focused on understanding how cells communicate and what happens when a viral pathogen co-opts cell surface proteins for receptors. Adenovirus is a common pathogen and, depending on the serotype, may cause a variety of disease symptoms. The receptor for adenovirus is also a receptor for Coxsackie B viruses and is named Coxsackie-Adenovirus Receptor (CAR). CAR normally behaves as a homotypic adhesion protein but several other functions, including intracellular protein trafficking and leukocyte transmigration, have recently been discovered.
Publications
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Kotha PNL, Sharma P, Kolawole AO, Yan R, Alghamri MS, Brockman TL, Gomez-Cambronero J, and Excoffon KJ. (2015) Adenovirus Entry from the Apical Surface of Polarized Epithelia is Facilitated by the Host Innate Immune Response. PLoS Pathogens. 11: e1004696.
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Yan R, Sharma P, Kolawole AO, Martin S, Readler J, Kotha PNL, Hostetler HA, and Excoffon KJ. (2015) The PDZ3 domain of the cellular scaffolding protein MAGI-1 interacts with the coxsackievirus and adenovirus receptor (CAR). The International Journal of Biochemistry & Cell Biology. 61: 29-34.
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Excoffon, KJ, Bowers, JB, and Sharma, P. (2014) Alternative Splicing of Viral Receptors: A Review of the Diverse Morphologies and Physiologies of Adenoviral Receptors. Recent Research Developments in Virology. 9: 1-24.
