Department of PHARMACOLOGY & TOXICOLOGY
Wright State University
United States of America
Education History: Doctorate of Pharmacy (Pharm.D.) Ohio Northern University, School of Pharmacy, Ada, Ohio, USA. Doctorate of Pharmacology (Ph.D.) University of Strathclyde, School of Pharmacy, Glasgow, Scotland, UK. Thesis: Stress-induced hyperinsulinemia. Advisor: Professor Brian Furman. Master of Science in Physiology & Pharmacology (MSc) University of Bradford, School of Pharmacy, England, UK. Thesis: Role of myofibroblasts in wound healing.Advisor: Professor Ian Naylor. Bachelor of Pharmacy (B.Pharm.) University of Khartoum, School of Pharmacy, SudanUniversity of Khartoum, School of Pharmacy, Sudan
Mechanisms of Disease-Diabetes and Chronic Kideny Disease. His current research interests focuse on: 1- Understanding and manipulating the Renin-Angiotensin System (RAS) relevant to hypertension and diabetes. 2- Use of MALDI- TOF-MS and SELDI-TOF-MS to develop and optimize miniaturized novel assays for quantitative evaluation of localized and circulating RAS. 2- Our recent work focused on the development of urinary Angiotensin Converting Enzyme (ACE2 ) and neprilysin (NEP) as biomarkers for early detection of Chronic Kidney Disease in diabetic patients. Their laboratory uses radiotelemetry, confocal microscopy, western blot and enzyme assay to investigate the effect of hyperglycemia on blood pressure, renal RAS and progression of CKD in murine model of diabetes and hypertension. Previous research interests were focused on extraction, purification and characterization of insulin mimetic molecules from Plasmodium yoelii. These molecules are related to Glycosylphosphatiylinositos (GPIs) which could have a potential as new antidiabetic agents. Research is funded by NHLBI, American Heart Association, WSU Boonshoft School of Medicine.
Grobe N, Leiva O, Morris M, Elased KM (2015). Loss of prolyl carboxypeptidase in two-kidney, one-clip Goldblatt hypertensive mice. PLoS One. 2015 Feb 23;10(2):e0117899. doi: 10.1371/journal.pone.0117899. PMID: 25706121.
Otaño-Rivera V, Boakye A, Grobe N, Almutairi M, Kursan S, Mattis L, Castrop H, Gurley S, Elased KM, Boivin G, Di Fulvio M (2016). A highly efficient strategy to determine genotypes of genetically engineered mice using genomic DNA purified from hair roots. Laboratory Animals, May 9, doi:10.1177/0023677216646088. PMID: 27166392.
Domenig O, Manzel A, Grobe N, Königshausen E, Kaltenecker CC, Kovarik JJ, Stegbauer J, Gurley SB, van Oyen D, Antlanger M, Bader M, Motta-Santos D, Santos RA, Elased KM, Säemann MD, Linker RA, Poglitsch M (2016). Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney. Sci Rep; 6:33678. doi: 10.1038/srep33678. PMID: 27649628.