Nadja Grobe

Biography

Education History: M.S. in Biochemistry (2005), Martin-Luther-University Halle-Wittenberg, Germany Ph.D. in Biological Sciences (2009), Martin-Luther-University Halle-Wittenberg, Germany Postdoctoral (2010-2013), Wright State University Boonshoft School of Medicine

Research Interest

Her laboratory studies complex hormonal peptide pathways involved in renal physiology and in the development of chronic kidney disease. It is well documented that the activation of the renin angiotensin system and increase of angiotensin II contribute to the pathophysiology of chronic kidney disease. The goal is to understand how manipulation of the renin angiotensin system and angiotensin II pathways may attenuate progression of renal disease and promote renoprotection in patients through improved diagnostic tools and targeted treatment strategies. To better understand the complex hormonal peptide pathways of the renin angiotensin system we established a new mass spectrometric imaging approach for the localization of in situ enzyme activity on tissue sections. Using this powerful mass spectrometric technique and genetic mouse models, we explore the complex mechanisms by which the peptide hormones of the renin angiotensin system are formed and metabolized locally in the kidney. Other routinely used techniques include renal and cardiovascular biomedical research techniques such as monitoring of renal, cardiovascular and metabolic parameters in conscious animals and small animal surgeries including placement of telemetry catheters for chronic blood pressure measurements, renal artery clips as a model of renal artery stenosis, and osmotic mini pumps for drug delivery.