Nancy J. Bigley
Ph.D.
Department of NEUROSCIENCE CELL BIO PHYSIO-COSM
Wright State University
United States of America
Biography
Professor, Neuroscience, Cell Biology & Physiology Professor, Pathology , works in Medical Sciences Bldg 063B, 3640 Colonel Glenn Hwy., Dayton, OH 45435-0001
Research Interest
The oobjective of her research is to understand the interactions between virus and the host defense system occurring between the first 12 to 24 hours of infection (innate immunity) which leads to susceptibility or resistance to disease (acquisition of adaptive immunity). Previously, the research projects under this objective dealt with: a gender-based difference to the pathogenesis of a picornavirus [the D variant of emcephalomyocarditis virus {EMCV-D] and a DNA vaccine for herpes simplex virus, type 1 (HSV-1). Her ongoing research involves HSV-1, cytokine signaling pathways, SOCS1/SOCS3 in inflammatory/anti-inflammatory cytokine pathways and cytoskeletal changes in macrophages polarized to the M1 and M2 phenotypes.
Publications
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Rogers JV, Hull BE, Fink PS, Chiou HC, Bigley NJ. 2000. Murine response to DNA encoding herpes simplex virus type-1 glycoprotein D targeted to the liver. Vaccine 18:1522-1530.
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Bigley NJ. 2015. Putative Roles of SOCS1: SOCS 3 Ratios in Development and Resolution of a Herpesvirus Lesion. J Cell Signal 1:101. doi:10.4172/jcs.1000101
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Bigley NJ. 2016. M1 and M2 Myeloid Cells in Inflammation. J Cell Signal 1:2
