Paula Ann Bubulya

Biography

ACADEMIC APPOINTMENTS Equity Fellow (2015 – 2017), Faculty Equity Fellow, College of Science and Mathematics, Wright State University, Dayton, OH Associate Chair (2013 – present), Department of Biological Sciences, Wright State University, Dayton, OH Associate Professor (2011-present), Department of Biological Sciences, Wright State University, Dayton, OH Assistant Professor (2005-2011), Department of Biological Sciences, Wright State University, Dayton, OH Postdoctoral Fellow (1999-2005), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. Research Advisor: Dr. David Spector Graduate Research Assistant (1996-1997), University of Toledo, Toledo, OH. Research Advisors: Dr. Keith Johnson and Dr. Peggy Wheelock Graduate Teaching Assistant (1993-1998), University of Toledo, Toledo, OH. Assistant Gross and Fetal Pathology Research Technician (1992-1993), Springborn Laboratories, Spencerville, OH. Undergraduate Research Assistant (1990-1992), University of Dayton, Dayton, OH. Research advisor: Panagiotis Tsonis   EDUCATION HISTORY 1988—1992, B.S. University of Dayton, Dayton, Ohio (Panagiotis Tsonis, Research Mentor) 1993—1998, Ph.D. University of Toledo, Toledo, Ohio (Keith R. Johnson, Research Mentor) 1999—2005, Postdoctoral Fellow, Cold Spring Harbor Laboratory, New York (David Spector, Research Mentor)    

Research Interest

Pre-mRNA processing is an essential feature of gene expression in eukaryotic cells. Coordination of gene expression and cell cycle progression is critical for cellular health. Nuclear speckles contain pre-mRNA processing factors, many of which remain to be characterized with regard to their specific nuclear functions and human disease relevance. Nearly 200 mRNA processing proteins have been identified, yet little is known about how these factors assemble into functional complexes within human cell nuclei. Our lab recently discovered that two related mRNA processing proteins, Btf and TRAP150, have critical roles in cell cycle regulation. Ongoing research in the Bubulya laboratory aims to define mechanistic functions for Btf, TRAP150 and SON in fundamental cellular processes including nuclear speckle organization, gene regulation, and cell cycle control.