Department of MECHANICAL & MATERIALS ENGINEERING
Wright State University
United States of America
Professor Sucosky was born in Nice (France), in 1976. He received his B.S. in mechanical engineering from the Ecole Nationale Supérieure d’Arts et Métiers, Paris, France, in 1996, and his M.S. and Ph.D. in mechanical engineering from the Georgia Institute of Technology, Atlanta, GA, in 2000 and 2005, respectively. From 2005 to 2008, he was a Postdoctoral Fellow with the Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA. From 2008 to 2015, he was an Assistant Professor with the Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN and the Director of the Multi-Scale Cardiovascular Bioengineering Laboratory. Since 2015, he has been an Associate Professor in Mechanical and Materials Engineering at Wright State University. His research interests are in biofluid mechanics, hemodynamics, cardiovascular mechanobiology, heart valve disease and cardiovascular medical devices. Dr. Sucosky was a recipient of a Postdoctoral Fellowship from the American Heart Association in 2006, a Young Investigator Award from the International Society for Applied Cardiovascular Biology in 2008, and a CAREER Award from the National Science Foundation in 2011. He is an elected fellow of the American Heart Association and a member of the American Society of Mechanical Engineers and the Biomedical Engineering Society.
Prof. Sucosky's interests are in the engineering discipline of fluid mechanics, with application to the mechanobiology of cardiovascular structures. Mechanobiology is an emerging field of science, which describes how mechanical forces affect the biology of living systems. It has provided a new way to think about the function of cells, tissues and organs, and is now considered a potential tool to elucidate disease mechanisms. Mechanobiology requires a multidisciplinary approach in which the detailed description of the mechanical environment and the thorough analysis of its effects on tissue biology are addressed in tandem. Historically, such studies have put more emphasis on the biological description of mechano-sensitive processes in simplified biological models than on the implementation of realistic mechanical stimuli due to the limited knowledge of the native mechanical environment and the challenge to replicate it on intact tissue in the laboratory. The lack of realistic laboratory models that duplicate the native tissue mechanical environment has hampered our understanding of mechano-sensitive disease processes and the development of early diagnosis and therapeutic modalities. Therefore, Prof. Sucosky's primary research interests are in the characterization of the native hemodynamics and the elucidation of the mechano-sensitive response in cardiovascular tissue and medical devices, with a particular focus on valvular disease. Prof. Sucosky's current interests are in: fluid-structure interactions (FSI) in the aortic valve and their relationship to valvular calcification flow abnormalities in the bicuspid aortic valve and their impact on aortopathy flow in hemodialysis vascular access and its role in intimal hyperplasia pathogenesis While these disorders have been studied for decades, the causality between hemodynamics and pathogenesis has never been rigorously established. Prof. Sucosky's Multi-Scale Cardiovascular Bioengineering Laboratory (MSCBL) has invested in the development of new approaches addressing the fluid mechanical and biological aspects of those disorders at the same level of depth, and is one of the few with such expertise.
Cao K, Sucosky P. Effect of Bicuspid Aortic Valve Cusp Fusion on Aorta Wall Shear Stress: Preliminary Computational Assessment and Implication for Aortic Dilation. World Journal of Cardiovascular Diseases. 2015; 5: 129-40. http://dx.doi.org/10.4236/wjcd.2015.56016
Sun L, Sucosky P. Bone Morphogenetic Protein-4 and Transforming Growth Factor-Beta1 in Acute Valvular Response to Supra-Physiologic Hemodynamic Stresses. World Journal of Cardiology. 2015; 7: http://dx.doi.org/331-43. 10.4330/wjc.v7.i6.331
Cao K, Sucosky P. Three-Dimensional Prediction of Regional and Temporal Wall Shear Stress Characteristics on Aortic Valve Leaflets. Computer Methods in Biomechanics and Biomedical Engineering. 2015; http://dx.doi.org/10.1080/10255842.2015.1052419