Craig Crews
Professor
Yale Department Of Chemistry
Yale University
United States of America
Biography
Education : B.A. University of Virginia, 1986 Ph.D. Harvard University, 1993 Postdoctoral Fellow, Harvard University, 1993-95 Honors : Burroughs Wellcome Young Investigator, 1996-99 Fellow of the Royal Society of Chemistry 2005 Bessel Research Award, Alexander von Humboldt Foundation, 2006 Editor, Chemistry&Biology, 2008
Research Interest
Each year, many promising natural products are identified as being biologically active in cell culture assays. Despite their proven in vitro efficacies, development of these ‘drug candidates’ into clinically useful therapeutic agents is an arduous procedure, often due to issues unrelated to the compound’s mechanism of action (e.g. poor pharmacokinetics, unfavorable side effects, etc.). While many of these compounds have limited therapeutic potential, investigation of their mechanism of action can provide new information about complex intracellular signaling pathways.
Publications
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A.K. Mandal, J.S. Schneekloth, Jr., K. Kuramochi, & C.M. Crews. Synthetic studies on amphidinolide B1. Org. Lett. 2006, 8, 427-30.
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J. S. Schneekloth, Jr., & C.M. Crews. Chemical Approaches to Controlling Intracellular Protein Degradation. ChemBioChem 2005, 6, 40-6.
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J.S. Schneekloth, Jr., F. Fonseca, M. Koldobskiy, A. Mandal, R. Deshaies, K. Sakamoto, & C. M. Crews. Chemical Genetic Control of Protein Levels: Selective in vivo Targeted Degradation. J. Am. Chem. Soc. 2004, 126, 3748-54.
