Yale Department Of Chemistry
United States of America
Education: Ph.D. Johns Hopkins University, 2007 Postdoctoral Fellowship, Harvard Medical School, 2007-2011
developing and systematically applying genome sequence-guided methods for the discovery of genetically encoded small molecules from mutualistic and pathogenic microorganisms. High-throughput genome sequencing of bacteria and fungi has revealed many highly unusual “orphan” biosynthetic gene clusters suspected of synthesizing novel, structurally diverse, and biologically active small molecules.
Healy, A. R., Nikolayevskiy, H., Patel, J., Crawford, J. M., Herzon, S. B. A mechanistic model for colibactin-induced genotoxicity. J. Am. Chem. Soc. 2016. 138 (48): 15563-15570.
Fischer, C. N., Trautman, E. P., Crawford, J. M., Stabb, E. V., Handelsman, J., Broderick, N. A. Metabolite exchange between microbiome members produces compounds that influence Drosphila behavior. eLife, 2017. 6:e18855.
Torring, T., Shames, S. R., Cho, W., Roy, C. R., and Crawford, J. M. Acyl-histidines: New N-acyl-amides from Legionella pneumophila. ChemBioChem. 2017. DOI: 10.1002/cbic.201600618