Jason Crawford
Assistant Professor
Yale Department Of Chemistry
Yale University
United States of America
Biography
Education: Ph.D. Johns Hopkins University, 2007 Postdoctoral Fellowship, Harvard Medical School, 2007-2011
Research Interest
developing and systematically applying genome sequence-guided methods for the discovery of genetically encoded small molecules from mutualistic and pathogenic microorganisms. High-throughput genome sequencing of bacteria and fungi has revealed many highly unusual “orphan” biosynthetic gene clusters suspected of synthesizing novel, structurally diverse, and biologically active small molecules.
Publications
-
Healy, A. R., Nikolayevskiy, H., Patel, J., Crawford, J. M., Herzon, S. B. A mechanistic model for colibactin-induced genotoxicity. J. Am. Chem. Soc. 2016. 138 (48): 15563-15570.
-
Fischer, C. N., Trautman, E. P., Crawford, J. M., Stabb, E. V., Handelsman, J., Broderick, N. A. Metabolite exchange between microbiome members produces compounds that influence Drosphila behavior. eLife, 2017. 6:e18855.
-
Torring, T., Shames, S. R., Cho, W., Roy, C. R., and Crawford, J. M. Acyl-histidines: New N-acyl-amides from Legionella pneumophila. ChemBioChem. 2017. DOI: 10.1002/cbic.201600618
