Emmanuel Burgos
Assistant Professor
Department of Biochemistry
Yeshiva University
United States of America
Biography
Emmanuel Burgos is an Assistant Professor in Yeshiva University in the Department of Biochemistry. Emmanuel Burgos research interests are in Nicotinamide recycling and targeted inhibition of NAMPT for the development of novel therapeutics. Chemoenzymatic synthesis of co-factors and HTS platforms to identify selective methyltransferases' inhibitors.
Research Interest
Nicotinamide recycling and targeted inhibition of NAMPT for the development of novel therapeutics. Chemoenzymatic synthesis of co-factors and HTS platforms to identify selective methyltransferases' inhibitors.
Publications
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Keisha Thomas, Scott A. Cameron, Steven C. Almo, Emmanuel S. Burgos, Shivali A. Gulab, and Vern L. Schramm. 2015. “Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.” Biochemistry, 54(15):2520-29 PMID: 25806409 doi: 10.1021/bi501487w
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Emmanuel S. Burgos, Carola Wilczek, Takashi Onikubo, Jeffrey B. Bonanno, Janina Jansong, Ulf Reimer, and David Shechter. 2015. “Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase.” J. Biol. Chem., 290(15):9674-89. PMID: 25713080 doi: 10.1074/jbc.M115.636894
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Emmanuel S. Burgos, Ryan O. Walters, Derek M. Huffman, and David Shechter. 2017. “A simplified characterization of S-adenosyl-L-methionine-consuming enzymes with 1-Step EZ-MTase: a universal and straightforward coupled-assay for in vitro and in vivo setting.” Chem. Sci., 8: 6601-12. doi: 10.1039/C7SC02830J
