Vyacheslav A. Adarichev
Associate Professor
Department of Medicine
Yeshiva University
United States of America
Biography
Dr. Adarichev is the 2003 recipient of The Sontag Foundation Fellowship of the Arthritis National Research Foundation. This is the third such special fellowship award thanks to the sponsorship of The Sontag Foundation of Jacksonville, Florida and their commitment to supporting rheumatoid arthritis research. Rheumatoid Arthritis (RA) is one of the most prevalent autoimmune diseases, affecting approximately 1% of all humans. RA is a systemic disease and may eventually affect not only inflammation of joints, but also other organs throughout the body such as kidneys, lungs and heart. Dr. Adarichev is studies RA at the genetic level, utilizing a mouse model for human RA, which resembles RA in clinical symptoms and genetics. He found that female animals are more susceptible than males, as in human RA patients. The investigation centered on the immunological and genetic mechanisms and effects of gender on arthritis. This information obtained may be
Research Interest
Research Interests: Genetic Control of Inflammation and Connective Tissue Remodeling in Arthritis and Spondyloarthritis.
Publications
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Glant TT, Adarichev VA, Boldizsar F, Besenyei T, Laszlo A, et al. (2012) Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis. Genes Immun 13: 336-45.
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Adarichev VA, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, et al. (2008) Congenic Strains Displaying Similar Clinical Phenotype of Arthritis Represent Different Immunologic Models of Inflammation. Genes Immun 9:591-601.
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Adarichev VA, Szanto S, Vegvari A, Szabo Z, Kis-Toth K, et al. (2008) Two loci on chromosome 15 control experimentally-induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation. J Immunol 181: 1307-14.
