Molecular Biology
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Jason R. Stagno

Staff Scientist
Center for Cancer Research
National Cancer Institute
United States Virgin Islands

Biography

Dr. Stagno conducted his graduate work in molecular biology at the University of California, Irvine in the lab of Professor Hartmut (Hudel) Luecke. His research focused on structure determination by X-ray crystallography of terminal uridylyltransferases (TUTases) to study substrate specificity, catalysis, and their role in RNA editing in trypanosomes. In 2009, he received his Ph.D. and joined Dr. Xinhua Ji's group as a postdoctoral fellow in the Macromolecular Crystallography Lab at CCR. Here, his research focused on structure determination of protein-nucleic acid complexes involved in bacteriophage lambda transcription antitermination and RNA supercoiling. In 2012, Dr. Stagno became a Health Science Policy Analyst in the Office of Science Policy, Office of the Director, NIH, where he was involved in major science policy issues involving biosafety, biosecurity, and so-called dual use research of concern. In June 2014, he returned to CCR, joining Yun-Xing Wang's group as a staff scientist in the Structural Biophysics Laboratory.

Research Interest

structural biology, molecular biology and biochemistry, X-ray crystallography, protein-nucleic acid interactions, transcription regulation, RNA editing

Publications

  • Stagno J, Aphasizheva I, Bruystens J, Luecke H, Aphasizhev R. Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization. Journal of molecular biology. 2010 Jun 11;399(3):464-75.

  • Stagno JR, Ma B, Li J, Altieri AS, Byrd RA, Ji X. Crystal structure of a plectonemic RNA supercoil. Nature communications. 2012;3:901.

  • Stagno JR, Liu Y, Bhandari YR, Conrad CE, Panja S, Swain M, Fan L, Nelson G, Li C, Wendel DR, White TA. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature. 2017 Jan 12;541(7636):242-6.

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