Pathology and Cell Biology
Columbia University Medical Center
"Andrew Franklin Assistant Professor of Pathology and Cell Biology "
Andrew Franklin interested in what beta-amyloid is normally doing in the brains of people without Alzheimer's disease. Beta-amyloid is present at low levels in the brain throughout life, and may have an important role in normal brain physiology. Ironically, there is some evidence that beta-amyloid actually facilitates neuronal connectivity and memory in people when it is present at low (normal) concentrations, and becomes toxic to neurons at higher concentrations. By studying its normal function and how it is regulated, we hope to understand better how it may accumulate in the brains of Alzheimer's patients
" Clain JB, Scherl S, Dos Reis L, Turk A, Wenig BM et al.( 2014) Extrathyroidal extension predicts extranodal extension in patients with positive lymph nodes: an important association that may affect clinical management. Thyroid. 24:951-7 "
"Turk AT, Wenig BM (2014) Pitfalls in the biopsy diagnosis of intraoral minor salivary gland neoplasms: diagnostic considerations and recommended approach. Adv Anat Pathol.21 : 1-11. "
"Teich AF and Arancio O. (2012) Is the Amyloid Hypothesis of Alzheimer’s disease therapeutically relevant? Biochemical Journal. 446 : 165-77. "
"Butler T, Ichise M, Teich AF, Gerard E, Osborne Jet al.( 2013) Imaging Inflammation in a Patient with Epilepsy Due to Focal Cortical Dysplasia. J Neuroimaging. :129-131. "
Teich AF, Patel M, Arancio O.( 2013) A Reliable Way to Detect Endogenous Murine β-Amyloid. PLOS ONE. Feb 8 :e55647 "