Medical Sciences

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Alberto Puig

Departmaent of Medicine
Harvard Medical School


 A native of Spain, Alberto Puig, MD PhD is an Associate Professor of Medicine at Harvard Medical School (HMS) and Director of the Clinician Educator Service in the Department of Medicine at Massachusetts General Hospital. After receiving a PhD in Biochemistry from Baylor College of Medicine for his studies on molecular chaperones and protein folding he completed his medical education and post-doctoral training in Internal Medicine at Baylor as well, including a year as Chief Medical Resident. Before coming to Boston in 2006, he was a member of the faculty in the Department of Medicine at the University of Texas School of Medicine in Houston where he was involved in curriculum design and implementation, and directed a variety of medical and clinical courses at UT-Houston, where he served as Associate Program Director of the Medicine Residency Program. Dr. Puig has continued his academic and professional career with a focus on medical and clinical education, curriculum design and bedside education. In his role as a clinician educator, he spends the majority of his time in the inpatient teaching general medicine and consultation services. He is Director of Principal Clinical Experience at Mass General for HMS undergraduate education and Director of the Practice of Medicine course, the clinical course in the Pathways curriculum at HMS. Dr. Puig has played a prominent role in the design and development of the curriculum, which started August 2015.Dr. Puig is the recipient of over 20 major teaching awards and is an avid student of the History of Medicine and a frequent lecturer on this topic. As a member of the Harvard Academy of Education, he devotes much of his efforts to Peer Observation of Teaching and Faculty Development. At the national level, he is a member of a number of academic and clinical professional societies and a voting member on the Executive Committee on Education for the Society of Hospital Medicine.

Research Interest

molecular chaperones Hospitality    


  • Puig A, Lyles MM, Noiva R, Gilbert HF. The role of the thiol/disulfide centers and peptide binding site in the chaperone and anti-chaperone activities of protein disulfide isomerase. J Biol Chem. 1994 Jul 22; 269(29):19128-35. PMID: 7913469.

  • Puig A, Gilbert HF. Anti-chaperone behavior of BiP during the protein disulfide isomerase-catalyzed refolding of reduced denatured lysozyme. J Biol Chem. 1994 Oct 14; 269(41):25889-96. PMID: 7929293.

  • Puig A, Primm TP, Surendran R, Lee JC, Ballard KD, Orkiszewski RS, Makarov V, Gilbert HF. A 21-kDa C-terminal fragment of protein-disulfide isomerase has isomerase, chaperone, and anti-chaperone activities. J Biol Chem. 1997 Dec 26; 272(52):32988-94. PMID: 9407079.

  • A. Puig. Case Files: Internal Medicine, Microscopic Hematuria and Glomerulonephritis. Editors: Faustinella, Patlan & Cruse; McGraw-Hill. 2004.

  • Pallais JC, Schlozman SC, Puig A, Purcell JJ, Stern TA. Fainting, swooning, and syncope. Prim Care Companion CNS Disord. 2011; 13(4). PMID: 22132356; PMCID: PMC3219519.

  • Finn K, Chiappa V, Puig A, Hunt DP. How to become a better clinical teacher: a collaborative peer observation process. Med Teach. 2011; 33(2):151-5. PMID: 21275544.

  • Puig A, Mino-Kenudson M, Dighe AS. Case records of the Massachusetts General Hospital. Case 13-2012. A 62-year-old man with paresthesias, weight loss, jaundice, and anemia. N Engl J Med. 2012 Apr 26; 366(17):1626-33. PMID: 22533579.

  • Puig A, Dighe AS. Case records of the Massachusetts General Hospital. Case 20-2013. A 29-year-old man with anemia and jaundice. N Engl J Med. 2013 Jun 27; 368(26):2502-9. PMID: 23802518.

  • Scripko PD, Amato AA, Puig A. Mystery case: a 63-year-old man with progressive proximal pain and weakness. Neurology. 2014 Jan 28; 82(4):e26-9. PMID: 24470605; PMCID: PMC3929200.

  • Blauvelt DG, Castellanos A, Stern TA, Puig A. Necrotising pneumonia and bronchiectasis in a previously healthy 30-year-old man. BMJ Case Rep. 2015 Jan 21; 2015. PMID: 25608981.

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